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Pharmacy Network Newsletter
February 2023 Issue No.2
Michelle Douglas
Genomics in Pharmacy practice - meet Michelle Douglas
Michelle Douglas is a Primary Care Network Pharmacist based in Blyth. Michelle is 1 of 12 pharmacists who took part in the NEY GMSA Familial Hypercholesterolaemia (FH) project.

‘I think it is very important to raise the awareness of FH, and to ensure discussions become ‘standard practice’ for high cholesterol and lipid optimisation reviews.’

Learn more about the project and how genomics impacted Michelle’s clinical practice
Lunch and Learn webinar series
Lunch and Learn Webinar
Lunch and Learn webinar - ‘Pharmacogenomics 101 and research in mental health’

Join our second lunch time webinar - 14th March 12:00-12:30 - Microsoft Teams

This webinar aims to raise awareness of pharmacogenomics, which is a new and exciting area for the pharmacy team. We will also discuss research and potential future application of using pharmacogenomics as a tool in guiding the prescription of psychotropic drugs.

Please click here to find out more and register
News and updates
Accelerating Genomic Medicine in the NHS
NHSE National Genomics Strategy launched!

'Accelerating Genomic Medicine in the NHS'
sets out the NHS England genomics strategy over the next 5 years.

One of the priority actions outlined in the strategy is ‘Driving the use of precision treatments and optimising the use of medicines through genomics.’

Pharmacy teams will be instrumental to the delivery precision medicine, implementation of pharmacogenomic services, and personalised care that improves patient safety, as part of a multi-professional team.

It is important all of the Pharmacy team have an understanding of genomics, and how and where genomics is relevant to their practice.
PROGRESS project
Delivering pharmacogenomics for the NHS - the PROGRESS project
The ambitious PROGRESS project (Pharmacogenetics Roll Out – Gauging Response to Service) is underway.

The research study currently underway in the NW region will investigate integration of pharmacogenetic data into electronic health records in primary care.

The study includes four types of medicine: 1) Statins, 2) Proton Pump Inhibitors, 3) Selective Serotonin Reuptake Inhibitors, and 4) Tricyclic Antidepressants.

The North East and Yorkshire are looking forward to taking part in this exciting research, as recruitment is extended across England in 2023.
Pharmacy Genomics Workforce Strategy
Pharmacy Genomics Workforce Strategy to be developed in 2023
Thank you! Thank you! to everyone who contributed to the discussions on the national pharmacy genomics workforce strategy!

NHS England and Health Education England held a joint face-to-face roundtable on 28th November 2023 to bring together pharmacy leadership, the multidisciplinary team and patient representatives.

The purpose of this was to inform and shape a pharmacy genomics workforce strategy and enable pharmacy’s role in embedding genomics into mainstream practice, to ensure patients get the best from their medicines in line with their individual genomic information. The strategy is planned for publication in 2023.

In the run up to the roundtable, several pre-recorded sessions were made available to set the scene. Access to these pre-session webinars are available via NHS Futures click here *

(*Please note, to access the workspace you will need to register for an NHS Futures account using your email address)
National Genomic Test Directory
Pharmacogenomic updates to the national genomic test directory – TPMT and NUDT15
The National Genomic Test Directory contains a list of nationally commissioned genomic tests in England and the patients who will be eligible to access a test.

TPMT and NUDT15 testing prior to thiopurine therapy for patients Acute Lymphoblastic Leukaemia has recently been included in the genomics test directory.

Thiopurine S-methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15) are key enzymes in the metabolism and inactivation thiopurines. Individuals with lower enzymatic activity are more likely to experience toxicity such as severe bone marrow suppression.
Hot off the press - PREPARE study published in The Lancet
The PREPARE study was published in The Lancet reporting on a 12-gene pharmacogenetic panel to prevent adverse drug reactions.

This randomised study across several European healthcare systems showed that pharmacogenomic-guided prescribing can reduce the incidence of clinically relevant adverse drug reactions by 30%.
A must read!
NICE conditionally recommends genetic test to prevent newborn babies going deaf
Use of aminoglycosides should be avoided in individuals with a mitochondrial variant associated with an increased risk of aminoglycoside-induced hearing loss.
The most common variant is m.1555A>G.

An independent NICE committee has conditionally recommended the use of the genedrive kit, a diagnostic test for detecting the m.1555A>G variant in newborn babies.

The test works with a swab of DNA from inside the newborn’s cheek and run it through the genedrive device to discover if the baby has the genetic variant. The results are displayed on screen in under an hour.

If the m.1555A>G variant is found, the baby can be treated with alternative antibiotics.

A consultation on the NICE recommendations ran until Tuesday 21 February 2023.

NICE recommends genetic test to prevent newborn babies going deaf | News | News | NICE
Genomics learning resources
Genomics 101
A short *free* online course that explores the fundamental principles of genomics and the applications in healthcare. Genomics 101: Genomics in Healthcare - Genomics Education Programme (
UK Clinical Pharmacy Association Genomics Committee
If you are a member of the UKPCA with an interest in genomics, there is a genomics forum and twitter account for regular genomics updates; @UKCPAgenomics.
The genomics committee are also providing a webinar for members on 25th April 2023. Genomics – what pharmacy staff need to know – UKCPA (
Familial Hypercholesterolaemia Gene Testing - One-Day Online Workshop
*FREE* Familial Hypercholesterolaemia Gene Testing One-Day Online Workshop for healthcare professionals providing care to patients and families with FH: including Endocrinology, Lipidology, Cardiology.

Familial Hypercholesterolaemia Gene Testing - 2023 Online Workshops - North East and Yorkshire Genomic Medicine Service North East and Yorkshire Genomic Medicine Service (
Just in case you missed!
Genomics in Pharmacy
Genomics in Pharmacy Practice
Genomics in Pharmacy Practice - Lunch and Learn - YouTube
Maybe it's MODY?
Maybe it's MODY?
Webinar - Maybe it’s MODY? An Introduction to Monogenic Diabetes (Jan 2023)
Call to action!
sign up here
Sign up to the NEY Genomic Medicine Pharmacy Network

Please help us co-create a network for pharmacists & pharmacy technicians wanting to make the best use of genomics in their practice for the benefit of patients in the North East & Yorkshire.

Please share and spread the word with colleagues!
You can register here
About this email
Why am I receiving this email?
Genomics is becoming increasingly relevant in everyday clinical practice in the NHS. At some point, you have provided your details, including your email address, to us at the NHS North East and Yorkshire Genomic Medicine Service (GMS).​

We would love to continue to keep you up-to-date with the GMS, genomics and our projects. We recently starting using a system called Tractivity to manage our communications. You can read our privacy notice here.​

You can opt out at any time by clicking the link at the bottom of emails you receive.

​If you have any concerns regarding the way we have stored or processed your data, then you can speak to the Information Commissioners Office.
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The North East and Yorkshire NHS Genomic Medicine Service (GMS) brings together regional Clinical Partners, the Genomic Laboratory Hub (GLH) and the Genomic Medicine Service Alliance (GMSA). Partner Trusts: The Newcastle upon Tyne Hospitals NHS Foundation Trust, The Leeds Teaching Hospitals NHS Trust, Sheffield Children’s NHS Foundation Trust and Sheffield Teaching Hospitals NHS Foundation Trust.
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Subscribing to our e-newsletter - North East and Yorkshire Genomic Medicine Service North East and Yorkshire Genomic Medicine Service (